discommode
A city may have the commodity of navigable rivers, or the discommodity of their overflowing.
She set out on her journey in the middle of winter, regardless of all discommodities of the weather.

SMART Vocabulary: related words and phrases

Inconvenience
a pain (in the neck)idiom
a pain in the arse/backsideidiom
aggravation
aggro
awkward
bother
bulky
disturbance
hassle
have fun and gamesidiom
imposition
incommode
incommodious
nuisance
palaver
pinprick
pisser
tempest
untoward
untowardly

You can also find related words, phrases, and synonyms in the topics:

Comfortable and uncomfortable